Diuretics should have proper diuretic activity, minor influences to serum electrolytes balance, no adverse effect to serum electrolytes balance, no adverse effect to renal and hepatic function, and no systemic adverse effect.
Clinical efficacy and adverse effect of azosemide were observed in 11 cases of edematous patients who had been treated in the Department of Medicine, Chungnam national University Hospital. Each patient was given one 60 mg azosemide tablet daily
for
7
days.
@ES The results were as follows.
@EN 1) The average age of the patients who treated with azosemide was 47.5±17.1 years and there were 5 males and 6 females. 8 patients were nephrotic syndrome, and 3 patients were diabetic nephropathy. Among them, 6 patients had mild azotemia.
2) Daily urine output after 1 day with azosemide medication increased significantly (p<0.05). body weight reduction was occurred after 1 day with azosemide medication, and it was decreased from 56.6±9.7 Kg to 52.9±9.2 Kg after 7 days(p<0.05).
3) Generalized edema was markedly improved in 7 patients (63.6%) after 7 days with azosemide medication.
4) the systolic and diastolic blood pressure were not changed significantly during azosemide emdication.
5) In 24 hours urine study, sodium, potassium and calcium excretion were significantly increased with azosemide (p<0.05) and phosphorus and magnesium excretion were also increased without significance.
6) The serum electrolyte concentrations such as sodium, potassium, cloride, magnesium, calcium and phosphorus, and uric acid were not changed significantly during azosemide medication.
7) BUN and serum creatinine levels and creatinine clearance rate were not changed significantly during azosemide medication.
8) No significant changes were observed in serum transaminase, total bilirubin, albumin, total cholesterol and triglyceride during azosemide medication.
9) One (9.1%) patient developed mild headahe but subsided spontaneously and no other side effects were observed.
With the results above, our data suggest that patients with 60 mg of azosemide took effective diuresis without alterations on blood pressure and serum electiolyte concentrations and the azosemide is a safe diuretics which did not alter renal or
hepatic
function.
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